Effectiveness of parenteral and oral typhoid vaccination in mice challenged with a Salmonella typhi-Salmonella typhimurium hybrid.
نویسندگان
چکیده
Live Salmonella typhi administered intraperitoneally, acetone-killed S. typhi administered intraperitoneally, and live S. typhi given orally, with their effectiveness decreasing in that order, protected Swiss white mice against death from challenge with a virulent Salmonella typhimurium hybrid expressing S. typhi antigens.
منابع مشابه
Evaluation of two Salmonella typhimurium hybrids as challenge organisms in a system for the assay of typhoid vaccines.
A mouse-virulent Salmonella typhimurium hybrid (H42), which expresses the Salmonella typhi Vi antigen in addition to S. typhi O antigens 9 and 12, and a mouse-virulent S. typhimurium hybrid (H1), which expresses only the 9 and 12 antigens of S. typhi, were compared in their behavior as challenge organisms in a system developed to assay the protective capabilities of typhoid vaccines. Swiss-Webs...
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Salmonella typhimurium hybrids expressing the S. typhosa antigens 9, d, and Vi were constructed by genetic crosses with an S. typhosa Hfr donor. The hybrids retained the same degree of mouse virulence as their S. typhimurium parent strain, the minimum lethal dose being less than 50 organisms when tested either in C(57) black mice or Swiss white mice. Vaccination of the Swiss white mice with S. ...
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Background and Aim: Salmonella Typhi belongs to the family Enterobacteriaceae, gram-negative bacilli and causes gastrointestinal diseases such as typhoid. This bacterium has a special structure and various genes, including the ompf gene (outer membrane protein). Recent studies have shown the possibility of using ompf in the development of a diagnostic tuberculosis vaccine. Therefore, the aim of...
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عنوان ژورنال:
- Infection and immunity
دوره 15 3 شماره
صفحات -
تاریخ انتشار 1977